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CTNNA1 (Catenin alpha-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer, Colorectal cancer and Cervical cancer.
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins.
Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes genetic literature 0.01, literature 0.92, genetic association 0.83, somatic mutation 0.43, animal model 0.60). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Cervical Adenocarcinoma, Colorectal Adenocarcinoma.
In plain words · CTNNA1 (Catenin alpha-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer, Colorectal cancer and Cervical cancer.
CTNNA1 (Catenin alpha-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer, Colorectal cancer and Cervical cancer.
Associates with the cytoplasmic domain of a variety of cadherins.
No product in this corpus aims at CTNNA1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1993. Earliest sequence paper UniProt cites for the protein: Oda et al, Biochem. Biophys. Res. Commun, 1993, "Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line". Source.
Sources: HGNC HGNC:2509 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35221 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000044115 (association with cancer (MONDO_0004992) 0.68; per-cancer scores at or above 0.5: colorectal cancer 0.59, gastric cancer 0.63 (GraphQL API, CC0)); IntOGen CTNNA1 (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Location: Cytoplasm, cytoskeleton; Cell junction, adherens junction; Cell membrane; Cell junction (UniProt). Locus 5q31.2 (HGNC).
Query for this target: (TITLE:"CTNNA1" OR ABSTRACT:"CTNNA1" OR TITLE:"catenin alpha 1" OR ABSTRACT:"catenin alpha 1" OR TITLE:"Catenin alpha-1" OR ABSTRACT:"Catenin alpha-1" OR TITLE:"CAP102" OR ABSTRACT:"CAP102") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CTNNA1, not a curated reading list.