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CTAG1B (Cancer/testis antigen 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma.
UniProt has no function text for P78358; HGNC names it "cancer/testis antigen 1B".
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Letetresgene Autoleucel. In OnCo, 1 product record names it (Letetresgene autoleucel).
In plain words · CTAG1B (Cancer/testis antigen 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma.
CTAG1B (Cancer/testis antigen 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma.
UniProt has no function text for P78358; HGNC names it "cancer/testis antigen 1B". Location: Cytoplasm (UniProt).
No product in this corpus aims at CTAG1B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Tumour-associated overexpression: HPA finds the RNA tissue enriched in normal testis, so the tumour and the normal tissue it comes from share the target and the medicine relies on the difference in level. HPA CTAG1B: RNA tissue enriched (testis 8 nTPM); high antibody staining in 1 normal tissue; highest cancer staining carcinoid (1 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Multiple myeloma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas CTAG1B tissue; Human Protein Atlas CTAG1B pathology; Open Targets ENSG00000184033 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Chen Y.-T. et al, Proc. Natl. Acad. Sci. U.S.A, 1997, "A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening". Source.
Sources: HGNC HGNC:2491 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P78358 (protein name, function text, keywords and locations (REST API)); CIViC gene CTAG1B (2 evidence items, 0 assertions, 2 variants; diseases: Multiple Myeloma, Myxoid Liposarcoma (GraphQL API, CC0))
UniProt has no function text for P78358; HGNC names it "cancer/testis antigen 1B". Location: Cytoplasm (UniProt). Locus Xq28 (HGNC).
RNA: tissue enriched (testis 8 nTPM), detected in single normal tissue.
Medium only: ovarian cancer, skin cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CTAG1B" OR ABSTRACT:"CTAG1B" OR TITLE:"cancer/testis antigen 1B" OR ABSTRACT:"cancer/testis antigen 1B" OR TITLE:"Cancer/testis antigen 1" OR ABSTRACT:"Cancer/testis antigen 1" OR TITLE:"NY-ESO-1" OR ABSTRACT:"NY-ESO-1" OR TITLE:"LAGE2B" OR ABSTRACT:"LAGE2B" OR TITLE:"LAGE2A" OR ABSTRACT:"LAGE2A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CTAG1B, not a curated reading list.