Loading
CSNK1A1 (Casein kinase I isoform alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Phosphorylates a large number of proteins. Participates in Wnt signalling.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.89, genetic association 0.17, somatic mutation 0.00).
In plain words · CSNK1A1 (Casein kinase I isoform alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
CSNK1A1 (Casein kinase I isoform alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Phosphorylates a large number of proteins.
No product in this corpus aims at CSNK1A1 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 1992. Earliest sequence paper UniProt cites for the protein: Brockman J.L. et al, Proc. Natl. Acad. Sci. U.S.A, 1992, "Cell cycle-dependent localization of casein kinase I to mitotic spindles". Source.
Sources: HGNC HGNC:2451 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P48729 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000113712 (association with cancer (MONDO_0004992) 0.59; (GraphQL API, CC0))
Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Phosphorylates a large number of proteins. Participates in Wnt signalling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. Location: Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Nucleus speckle (UniProt). Locus 5q32 (HGNC).
Query for this target: (TITLE:"CSNK1A1" OR ABSTRACT:"CSNK1A1" OR TITLE:"casein kinase 1 alpha 1" OR ABSTRACT:"casein kinase 1 alpha 1" OR TITLE:"Casein kinase I isoform alpha" OR ABSTRACT:"Casein kinase I isoform alpha" OR TITLE:"CK1" OR ABSTRACT:"CK1" OR TITLE:"CK1a" OR ABSTRACT:"CK1a" OR TITLE:"CK1alpha" OR ABSTRACT:"CK1alpha") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CSNK1A1, not a curated reading list.