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CREB3L2 (Cyclic AMP-responsive element-binding protein 3-like protein 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas, Breast cancer and Lung cancer.
Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.85, animal model 0.54, genetic association 0.00, somatic mutation 0.98).
In plain words · CREB3L2 (Cyclic AMP-responsive element-binding protein 3-like protein 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas, Breast cancer and Lung cancer.
CREB3L2 (Cyclic AMP-responsive element-binding protein 3-like protein 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas, Breast cancer and Lung cancer.
Transcription factor involved in unfolded protein response (UPR).
No product in this corpus aims at CREB3L2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2003. Earliest sequence paper UniProt cites for the protein: Storlazzi C.T. et al, Hum. Mol. Genet, 2003, "Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma". Source.
Sources: HGNC HGNC:23720 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q70SY1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000182158 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: sarcoma 0.58, breast cancer 0.51, lung cancer 0.50 (GraphQL API, CC0))
Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. Location: Endoplasmic reticulum membrane; Nucleus (UniProt). Locus 7q33 (HGNC).
Query for this target: (TITLE:"CREB3L2" OR ABSTRACT:"CREB3L2" OR TITLE:"cAMP responsive element binding protein 3 like 2" OR ABSTRACT:"cAMP responsive element binding protein 3 like 2" OR TITLE:"Cyclic AMP-responsive element-binding protein 3-like protein 2" OR ABSTRACT:"Cyclic AMP-responsive element-binding protein 3-like protein 2" OR TITLE:"BBF2H7" OR ABSTRACT:"BBF2H7" OR TITLE:"TCAG_1951439" OR ABSTRACT:"TCAG_1951439") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CREB3L2, not a curated reading list.