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COL1A1 (Collagen alpha-1(I) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Anal cancer, Pancreatic ductal adenocarcinoma and 3 more.
Type I collagen is a member of group I collagen (fibrillar forming collagen).
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.98, animal model 0.57, genetic association 0.00, somatic mutation 0.79). IntOGen calls it a driver in 5 cohorts (2 activating, 3 loss-of-function), covering Anal Squamous Cell Carcinoma, Glioblastoma Multiforme, Melanoma, Pancreatic Adenocarcinoma, Plasma Cell Myeloma.
In plain words · COL1A1 (Collagen alpha-1(I) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Anal cancer, Pancreatic ductal adenocarcinoma and 3 more.
COL1A1 (Collagen alpha-1(I) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Anal cancer, Pancreatic ductal adenocarcinoma and 3 more.
Type I collagen is a member of group I collagen (fibrillar forming collagen). Location: Secreted, extracellular space, extracellular matrix (UniProt).
No product in this corpus aims at COL1A1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1970. Earliest sequence paper UniProt cites for the protein: Click E.M. et al, Biochemistry, 1970, "Isolation and characterization of the cyanogen bromide peptides from the alpha 1 and alpha 2 chains of human skin collagen". Source.
Sources: HGNC HGNC:2197 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02452 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108821 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: sarcoma 0.59 (GraphQL API, CC0)); IntOGen COL1A1 (driver in 5 cohorts (Act 2, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Type I collagen is a member of group I collagen (fibrillar forming collagen). Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 17q21.33 (HGNC).
Query for this target: (TITLE:"COL1A1" OR ABSTRACT:"COL1A1" OR TITLE:"collagen type I alpha 1 chain" OR ABSTRACT:"collagen type I alpha 1 chain" OR TITLE:"Collagen alpha-1 I chain" OR ABSTRACT:"Collagen alpha-1 I chain" OR TITLE:"OI4" OR ABSTRACT:"OI4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about COL1A1, not a curated reading list.
Shares Anal cancer (squamous cell carcinoma), IntOGen, Melanoma, Open Targets Platform.
Shares Anal cancer (squamous cell carcinoma), IntOGen, Open Targets Platform.
Shares Anal cancer (squamous cell carcinoma), Pancreatic ductal adenocarcinoma.
Shares Anal cancer (squamous cell carcinoma), Pancreatic ductal adenocarcinoma.
Shares Anal cancer (squamous cell carcinoma), Pancreatic ductal adenocarcinoma.
Shares Anal cancer (squamous cell carcinoma), Pancreatic ductal adenocarcinoma.
Shares Anal cancer (squamous cell carcinoma), IntOGen, Open Targets Platform, Pancreatic ductal adenocarcinoma.
Shares Anal cancer (squamous cell carcinoma), Multiple myeloma, Pancreatic ductal adenocarcinoma.