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CNKSR1 (Connector enhancer of kinase suppressor of ras 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
May function as an adapter protein or regulator of Ras signalling pathways.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.65, affected pathway 0.97, genetic association 0.00).
In plain words · CNKSR1 (Connector enhancer of kinase suppressor of ras 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
CNKSR1 (Connector enhancer of kinase suppressor of ras 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
May function as an adapter protein or regulator of Ras signalling pathways. Location: Cytoplasm; Membrane (UniProt).
No product in this corpus aims at CNKSR1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Therrien et al, Cell, 1998, "CNK, a RAF-binding multidomain protein required for RAS signaling". Source.
Sources: HGNC HGNC:19700 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q969H4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000142675 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
May function as an adapter protein or regulator of Ras signalling pathways. Location: Cytoplasm; Membrane (UniProt). Locus 1p36.11 (HGNC).
Query for this target: (TITLE:"CNKSR1" OR ABSTRACT:"CNKSR1" OR TITLE:"connector enhancer of kinase suppressor of Ras 1" OR ABSTRACT:"connector enhancer of kinase suppressor of Ras 1" OR TITLE:"Connector enhancer of kinase suppressor of ras 1" OR ABSTRACT:"Connector enhancer of kinase suppressor of ras 1" OR TITLE:"CNK1" OR ABSTRACT:"CNK1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CNKSR1, not a curated reading list.