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CNBP (CCHC-type zinc finger nucleic acid binding protein) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.88, animal model 0.50, genetic association 0.00, somatic mutation 0.93).
In plain words · CNBP (CCHC-type zinc finger nucleic acid binding protein) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
CNBP (CCHC-type zinc finger nucleic acid binding protein) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter.
No product in this corpus aims at CNBP yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1989. Earliest sequence paper UniProt cites for the protein: Rajavashisth T.B. et al, Science, 1989, "Identification of a zinc finger protein that binds to the sterol regulatory element". Source.
Sources: HGNC HGNC:13164 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62633 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000169714 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner. Binds G-rich elements in target mRNA coding sequences. Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs. Binds to RNA. Location: Nucleus; Cytoplasm; Endoplasmic reticulum (UniProt). Locus 3q21.3 (HGNC).
Query for this target: (TITLE:"CNBP" OR ABSTRACT:"CNBP" OR TITLE:"CCHC-type zinc finger nucleic acid binding protein" OR ABSTRACT:"CCHC-type zinc finger nucleic acid binding protein" OR TITLE:"RNF163" OR ABSTRACT:"RNF163" OR TITLE:"ZCCHC22" OR ABSTRACT:"ZCCHC22" OR TITLE:"CNBP1" OR ABSTRACT:"CNBP1" OR TITLE:"DM2" OR ABSTRACT:"DM2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CNBP, not a curated reading list.