Loading
CLTCL1 (Clathrin heavy chain 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Prostate cancer, Skin cancer and 2 more.
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.31, genetic association 0.08, somatic mutation 0.84). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Hepatocellular Carcinoma, Prostate Adenocarcinoma.
In plain words · CLTCL1 (Clathrin heavy chain 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Prostate cancer, Skin cancer and 2 more.
CLTCL1 (Clathrin heavy chain 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Prostate cancer, Skin cancer and 2 more.
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
No product in this corpus aims at CLTCL1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1996. Earliest sequence paper UniProt cites for the protein: Sirotkin et al, Hum. Mol. Genet, 1996, "Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome". Source.
Sources: HGNC HGNC:2093 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P53675 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000070371 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: skin cancer 0.52, breast cancer 0.51, lung cancer 0.51 (GraphQL API, CC0)); IntOGen CLTCL1 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Location: Cytoplasmic vesicle membrane; Membrane, coated pit (UniProt). Locus 22q11.21 (HGNC).
Query for this target: (TITLE:"CLTCL1" OR ABSTRACT:"CLTCL1" OR TITLE:"clathrin heavy chain like 1" OR ABSTRACT:"clathrin heavy chain like 1" OR TITLE:"Clathrin heavy chain 2" OR ABSTRACT:"Clathrin heavy chain 2" OR TITLE:"CLH22" OR ABSTRACT:"CLH22" OR TITLE:"CHC22" OR ABSTRACT:"CHC22" OR TITLE:"CLTCL" OR ABSTRACT:"CLTCL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CLTCL1, not a curated reading list.