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A tight-junction protein normally found only in the embryo that reappears in ovarian, testicular, endometrial and lung cancers, making it a clean target for ADCs and CAR-T.
Claudin 6 is an oncofetal antigen essentially absent from adult tissue, unlike its relative CLDN18.2 (gastric mucosa). It is expressed in ~50-60% of ovarian and testicular germ cell tumours, and subsets of endometrial, lung and gastric cancers. TORL-1-23 (ADC) is in phase 2/3 in ovarian cancer; BNT211 (CAR-T with an amplifying mRNA vaccine, CARVac) reported responses in germ cell tumours; DS-9606 is another ADC. Sequence similarity to CLDN9 and CLDN4 requires highly selective antibodies.
In plain words · A tight-junction protein normally found only in the embryo that reappears in ovarian, testicular, endometrial and lung cancers, making it a clean target for ADCs and CAR-T.
A tight-junction protein normally found only in the embryo that reappears in ovarian, testicular, endometrial and lung cancers, making it a clean target for ADCs and CAR-T.
Four-transmembrane tight-junction claudin expressed in embryonic epithelia and germ cells; silenced after development, re-expressed in cancers via epigenetic derepression.
No product in this corpus aims at Claudin 6 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
First described 1999. Earliest sequence paper UniProt cites for the protein: Keen T.J. et al, 1999. Source.
Four-transmembrane tight-junction claudin expressed in embryonic epithelia and germ cells; silenced after development, re-expressed in cancers via epigenetic derepression.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Testicular germ cell tumours | 90% | IHC positivity | ||
| Ovarian cancer | 50-60% | IHC positivity | varies by antibody and cutoff |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
Query for this target: (TITLE:"Claudin 6" OR ABSTRACT:"Claudin 6" OR TITLE:"CLDN6" OR ABSTRACT:"CLDN6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Claudin 6, not a curated reading list.
Shares Daiichi Sankyo, Endometrial cancer, Antibody-drug conjugate (ADC), Non-small-cell lung cancer.
Shares Daiichi Sankyo, Endometrial cancer, Antibody-drug conjugate (ADC).
Shares BioNTech, Endometrial cancer, Antibody-drug conjugate (ADC).
Shares Daiichi Sankyo, Antibody-drug conjugate (ADC), Ovarian cancer.
Shares Daiichi Sankyo, Antibody-drug conjugate (ADC), Non-small-cell lung cancer.
Shares Claudin 18.2, Ovarian cancer, Non-small-cell lung cancer.
Shares Daiichi Sankyo, Antibody-drug conjugate (ADC), Non-small-cell lung cancer.