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CFLAR (CASP8 and FADD-like apoptosis regulator) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signalling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex.
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Bicalutamide.
In plain words · CFLAR (CASP8 and FADD-like apoptosis regulator) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
CFLAR (CASP8 and FADD-like apoptosis regulator) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis.
No product in this corpus aims at CFLAR yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA CFLAR: RNA low tissue specificity; blood lineage lineage enriched (granulocytes 394 nTPM); no normal tissue stained high; highest cancer staining colorectal cancer (6 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Prostate cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas CFLAR tissue; Open Targets ENSG00000003402 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Shu H.-B. et al, Immunity, 1997, "Casper is a FADD- and caspase-related inducer of apoptosis". Source.
Sources: HGNC HGNC:1876 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15519 (protein name, function text, keywords and locations (REST API)); CIViC gene CFLAR (1 evidence items, 0 assertions, 2 variants; diseases: Prostate Cancer (GraphQL API, CC0))
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signalling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. Locus 2q33.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues. Blood: lineage enriched (granulocytes 394 nTPM).
No normal tissue stained high.
Medium only: lymphoma, melanoma, pancreatic cancer, renal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CFLAR" OR ABSTRACT:"CFLAR" OR TITLE:"CASP8 and FADD like apoptosis regulator" OR ABSTRACT:"CASP8 and FADD like apoptosis regulator" OR TITLE:"CASP8 and FADD-like apoptosis regulator" OR ABSTRACT:"CASP8 and FADD-like apoptosis regulator" OR TITLE:"Casper" OR ABSTRACT:"Casper" OR TITLE:"CLARP" OR ABSTRACT:"CLARP" OR TITLE:"FLAME" OR ABSTRACT:"FLAME") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CFLAR, not a curated reading list.