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CDKAL1 (Threonylcarbamoyladenosine tRNA methylthiotransferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Catalyses the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.72, animal model 0.46, genetic association 0.63).
In plain words · CDKAL1 (Threonylcarbamoyladenosine tRNA methylthiotransferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
CDKAL1 (Threonylcarbamoyladenosine tRNA methylthiotransferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Catalyses the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
No product in this corpus aims at CDKAL1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2003. Earliest sequence paper UniProt cites for the protein: Mungall A.J. et al, Nature, 2003, "The DNA sequence and analysis of human chromosome 6". Source.
Sources: HGNC HGNC:21050 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5VV42 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000145996 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Catalyses the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Location: Endoplasmic reticulum membrane (UniProt). Locus 6p22.3 (HGNC).
Query for this target: (TITLE:"CDKAL1" OR ABSTRACT:"CDKAL1" OR TITLE:"CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase" OR ABSTRACT:"CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase" OR TITLE:"Threonylcarbamoyladenosine tRNA methylthiotransferase" OR ABSTRACT:"Threonylcarbamoyladenosine tRNA methylthiotransferase" OR TITLE:"FLJ20342" OR ABSTRACT:"FLJ20342") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDKAL1, not a curated reading list.