Loading
CDC37 (Hsp90 co-chaperone Cdc37) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilisation and promotion of their activity. Inhibits HSP90AA1 ATPase activity.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.99, genetic association 0.00).
In plain words · CDC37 (Hsp90 co-chaperone Cdc37) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
CDC37 (Hsp90 co-chaperone Cdc37) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilisation and promotion of their activity. Inhibits HSP90AA1 ATPase activity.
No product in this corpus aims at CDC37 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1996. Earliest sequence paper UniProt cites for the protein: Stepanova et al, Genes Dev, 1996, "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4". Source.
Sources: HGNC HGNC:1735 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16543 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000105401 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilisation and promotion of their activity. Inhibits HSP90AA1 ATPase activity. Location: Cytoplasm (UniProt). Locus 19p13.2 (HGNC).
Query for this target: (TITLE:"CDC37" OR ABSTRACT:"CDC37" OR TITLE:"cell division cycle 37, HSP90 cochaperone" OR ABSTRACT:"cell division cycle 37, HSP90 cochaperone" OR TITLE:"Hsp90 co-chaperone Cdc37" OR ABSTRACT:"Hsp90 co-chaperone Cdc37" OR TITLE:"P50CDC37" OR ABSTRACT:"P50CDC37") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDC37, not a curated reading list.