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CD83 (CD83 antigen) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · CD83 (CD83 antigen) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
CD83 (CD83 antigen) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation.
No product in this corpus aims at CD83 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA CD83: RNA tissue enhanced (bone marrow 198 nTPM); high antibody staining in 1 normal tissue; highest cancer staining lymphoma (1 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas CD83 tissue; Open Targets ENSG00000112149 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Zhou L.-J. et al, J. Immunol, 1992, "A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily". Source.
Sources: HGNC HGNC:1703 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q01151 (protein name, function text, keywords and locations (REST API)); CIViC gene CD83 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation. In addition, acts as an important modulator of protective responses against acute infections. Location: Membrane (UniProt). Locus 6p23 (HGNC).
RNA: tissue enhanced (bone marrow 198 nTPM), detected in all normal tissues.
Medium: Appendix, Bone marrow, Lung, Lymph node, Spleen, Testis, Tonsil.
Medium only: breast cancer, endometrial cancer, lung cancer, melanoma.
HPA CD83 tissue · HPA CD83 pathology · HPA protein class: CD markers
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CD83" OR ABSTRACT:"CD83" OR TITLE:"CD83 molecule" OR ABSTRACT:"CD83 molecule" OR TITLE:"CD83 antigen" OR ABSTRACT:"CD83 antigen" OR TITLE:"HB15" OR ABSTRACT:"HB15" OR TITLE:"BL11" OR ABSTRACT:"BL11") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD83, not a curated reading list.