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CCNH (Cyclin-H) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalysing the activating threonine phosphorylation of CDKs. Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK. CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.35, somatic mutation 0.74).
In plain words · CCNH (Cyclin-H) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
CCNH (Cyclin-H) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalysing the activating threonine phosphorylation of CDKs. Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK.
No product in this corpus aims at CCNH yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1994. Earliest sequence paper UniProt cites for the protein: Maekelae T.P. et al, Nature, 1994, "A cyclin associated with the CDK-activating kinase MO15". Source.
Sources: HGNC HGNC:1594 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P51946 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000134480 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalysing the activating threonine phosphorylation of CDKs. Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK. CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Location: Nucleus (UniProt). Locus 5q14.3 (HGNC).
Query for this target: (TITLE:"CCNH" OR ABSTRACT:"CCNH" OR TITLE:"cyclin H" OR ABSTRACT:"cyclin H" OR TITLE:"Cyclin-H" OR ABSTRACT:"Cyclin-H" OR TITLE:"p34" OR ABSTRACT:"p34" OR TITLE:"p37" OR ABSTRACT:"p37" OR TITLE:"CycH" OR ABSTRACT:"CycH") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCNH, not a curated reading list.