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CARS1 (Cysteine--tRNA ligase, cytoplasmic) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Lung cancer and Melanoma.
Catalyses the ATP-dependent ligation of cysteine to tRNA(Cys).
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.54, affected pathway 0.76, genetic association 0.00, somatic mutation 0.97).
In plain words · CARS1 (Cysteine--tRNA ligase, cytoplasmic) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Lung cancer and Melanoma.
CARS1 (Cysteine--tRNA ligase, cytoplasmic) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Lung cancer and Melanoma.
Catalyses the ATP-dependent ligation of cysteine to tRNA(Cys). Location: Cytoplasm (UniProt).
No product in this corpus aims at CARS1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1994. Earliest sequence paper UniProt cites for the protein: Cruzen M.E. et al, DNA Seq, 1994, "Nucleotide and deduced amino acid sequence of human cysteinyl-tRNA synthetase". Source.
Sources: HGNC HGNC:1493 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P49589 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000110619 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: melanoma 0.50, skin cancer 0.54, lung cancer 0.50 (GraphQL API, CC0))
Catalyses the ATP-dependent ligation of cysteine to tRNA(Cys). Location: Cytoplasm (UniProt). Locus 11p15.4 (HGNC).
Query for this target: (TITLE:"CARS1" OR ABSTRACT:"CARS1" OR TITLE:"cysteinyl-tRNA synthetase 1" OR ABSTRACT:"cysteinyl-tRNA synthetase 1" OR TITLE:"Cysteine--tRNA ligase, cytoplasmic" OR ABSTRACT:"Cysteine--tRNA ligase, cytoplasmic") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CARS1, not a curated reading list.