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BUB1B (Mitotic checkpoint serine/threonine-protein kinase BUB1 beta) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Skin cancer, Breast cancer and 3 more.
Kinase which is a component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle. The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint. The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition.
Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes genetic literature 0.68, literature 0.98, genetic association 0.55, somatic mutation 0.89, animal model 0.61).
In plain words · BUB1B (Mitotic checkpoint serine/threonine-protein kinase BUB1 beta) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Skin cancer, Breast cancer and 3 more.
BUB1B (Mitotic checkpoint serine/threonine-protein kinase BUB1 beta) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Skin cancer, Breast cancer and 3 more.
Kinase which is a component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle.
No product in this corpus aims at BUB1B yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 1998. Earliest sequence paper UniProt cites for the protein: Donadelli et al, Biochem. Biophys. Res. Commun, 1998, "Identification of a novel gene -- SSK1 -- in human endothelial cells exposed to shear stress". Source.
Sources: HGNC HGNC:1149 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60566 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156970 (association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: colorectal cancer 0.57, gastric cancer 0.50, ovarian cancer 0.51, melanoma 0.52, skin cancer 0.55, breast cancer 0.53 (GraphQL API, CC0))
Kinase which is a component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle. The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint. The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition. When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase. MCC also monitors kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localisation of CENPE. Location: Cytoplasm; Nucleus; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 15q15.1 (HGNC).
Query for this target: (TITLE:"BUB1B" OR ABSTRACT:"BUB1B" OR TITLE:"BUB1 mitotic checkpoint serine/threonine kinase B" OR ABSTRACT:"BUB1 mitotic checkpoint serine/threonine kinase B" OR TITLE:"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta" OR ABSTRACT:"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta" OR TITLE:"BUBR1" OR ABSTRACT:"BUBR1" OR TITLE:"MAD3L" OR ABSTRACT:"MAD3L" OR TITLE:"Bub1A" OR ABSTRACT:"Bub1A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BUB1B, not a curated reading list.
Shares Mitosis & the spindle assembly checkpoint, Open Targets Platform.
Shares Mitosis & the spindle assembly checkpoint, Open Targets Platform.
Shares Mitosis & the spindle assembly checkpoint, Gastric & gastro-oesophageal junction cancer, Open Targets Platform, Colorectal cancer.