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BTC (Probetacellulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.48, affected pathway 0.95, genetic association 0.35).
In plain words · BTC (Probetacellulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
BTC (Probetacellulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
No product in this corpus aims at BTC yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1993. Earliest sequence paper UniProt cites for the protein: Sasada et al, Biochem. Biophys. Res. Commun, 1993, "Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family". Source.
Sources: HGNC HGNC:1121 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35070 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000174808 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Location: Secreted, extracellular space; Cell membrane (UniProt). Locus 4q13.3 (HGNC).
Query for this target: (TITLE:"BTC" OR ABSTRACT:"BTC" OR TITLE:"betacellulin" OR ABSTRACT:"betacellulin" OR TITLE:"Probetacellulin" OR ABSTRACT:"Probetacellulin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BTC, not a curated reading list.