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BRD7 (Bromodomain-containing protein 7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Melanoma.
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signalling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.73). IntOGen calls it a driver in 4 cohorts (0 activating, 4 loss-of-function), covering Hepatocellular Carcinoma, Melanoma.
In plain words · BRD7 (Bromodomain-containing protein 7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Melanoma.
BRD7 (Bromodomain-containing protein 7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Melanoma.
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling.
No product in this corpus aims at BRD7 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1999. Earliest sequence paper UniProt cites for the protein: Yu et al, 1999. Source.
Sources: HGNC HGNC:14310 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NPI1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166164 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: hepatocellular carcinoma 0.51 (GraphQL API, CC0)); IntOGen BRD7 (driver in 4 cohorts (Act 0, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signalling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. Transcriptional corepressor that down-regulates the expression of target genes. Location: Nucleus; Chromosome (UniProt). Locus 16q12.1 (HGNC).
Query for this target: (TITLE:"BRD7" OR ABSTRACT:"BRD7" OR TITLE:"bromodomain containing 7" OR ABSTRACT:"bromodomain containing 7" OR TITLE:"Bromodomain-containing protein 7" OR ABSTRACT:"Bromodomain-containing protein 7" OR TITLE:"CELTIX1" OR ABSTRACT:"CELTIX1" OR TITLE:"BP75" OR ABSTRACT:"BP75" OR TITLE:"SMARCI1" OR ABSTRACT:"SMARCI1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BRD7, not a curated reading list.