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BAZ1A (Bromodomain adjacent to zinc finger domain protein 1A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Small-cell lung cancer.
Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and centre-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the centre of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.59, genetic association 0.51, somatic mutation 0.49). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Small Cell Lung Cancer.
In plain words · BAZ1A (Bromodomain adjacent to zinc finger domain protein 1A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Small-cell lung cancer.
BAZ1A (Bromodomain adjacent to zinc finger domain protein 1A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Small-cell lung cancer.
Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and centre-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair.
No product in this corpus aims at BAZ1A yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1999. Earliest sequence paper UniProt cites for the protein: Ye et al, 1999, "Human partial CDS from CD34+ stem cells". Source.
Sources: HGNC HGNC:960 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NRL2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198604 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0)); IntOGen BAZ1A (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and centre-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the centre of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. May have a role in nuclear receptor-mediated transcription repression. Location: Nucleus (UniProt). Locus 14q13.1-q13.2 (HGNC).
Query for this target: (TITLE:"BAZ1A" OR ABSTRACT:"BAZ1A" OR TITLE:"bromodomain adjacent to zinc finger domain 1A" OR ABSTRACT:"bromodomain adjacent to zinc finger domain 1A" OR TITLE:"Bromodomain adjacent to zinc finger domain protein 1A" OR ABSTRACT:"Bromodomain adjacent to zinc finger domain protein 1A" OR TITLE:"hACF1" OR ABSTRACT:"hACF1" OR TITLE:"ACF1" OR ABSTRACT:"ACF1" OR TITLE:"WALp1" OR ABSTRACT:"WALp1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BAZ1A, not a curated reading list.