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BAG4 (BAG family molecular chaperone regulator 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signalling. Negative regulator of PRKN translocation to damaged mitochondria.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.88, affected pathway 0.95, genetic association 0.00).
In plain words · BAG4 (BAG family molecular chaperone regulator 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
BAG4 (BAG family molecular chaperone regulator 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signalling.
No product in this corpus aims at BAG4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Takayama et al, J. Biol. Chem, 1999, "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". Source.
Sources: HGNC HGNC:940 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95429 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156735 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signalling. Negative regulator of PRKN translocation to damaged mitochondria. Location: Cytoplasm (UniProt). Locus 8p11.23 (HGNC).
Query for this target: (TITLE:"BAG4" OR ABSTRACT:"BAG4" OR TITLE:"BAG cochaperone 4" OR ABSTRACT:"BAG cochaperone 4" OR TITLE:"BAG family molecular chaperone regulator 4" OR ABSTRACT:"BAG family molecular chaperone regulator 4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BAG4, not a curated reading list.