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B4GALT1 (Beta-1,4-galactosyltransferase 1) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma.
Galactosyltransferase acting in the Golgi stacks. Catalyses the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans. Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · B4GALT1 (Beta-1,4-galactosyltransferase 1) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma.
B4GALT1 (Beta-1,4-galactosyltransferase 1) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma.
Galactosyltransferase acting in the Golgi stacks.
No product in this corpus aims at B4GALT1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA B4GALT1: RNA low tissue specificity; high antibody staining in 24 normal tissues; highest cancer staining prostate cancer (12 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Renal cell carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas B4GALT1 tissue; Open Targets ENSG00000086062 associations
First described 1986. Earliest sequence paper UniProt cites for the protein: Appert H.E. et al, Biochem. Biophys. Res. Commun, 1986, "Isolation of a cDNA coding for human galactosyltransferase". Source.
Sources: HGNC HGNC:924 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15291 (protein name, function text, keywords and locations (REST API)); CIViC gene B4GALT1 (1 evidence items, 0 assertions, 1 variants; diseases: Renal Cell Carcinoma (GraphQL API, CC0))
Galactosyltransferase acting in the Golgi stacks. Catalyses the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans. Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms. Galactosylates complex-type N-glycans attached on the fragment crystallizable (Fc) of immunoglobulin-gamma isotypes (IgGs), a prerequisite for antibody glycan sialylation and related anti-inflammatory effector functions. Can also transfer a Gal residue to free GlcNAc to form N-acetyllactosamine. With LALBA/alpha-lactalbumin forms the lactose synthase complex responsible for production of large amounts of lactose in the lactating mammary gland. Location: Golgi apparatus, Golgi stack membrane; Cell membrane; Cell surface; Cell projection, filopodium (UniProt). Locus 9p21.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Bone marrow, Breast, Esophagus, Lung, Oral mucosa, Pancreas, Salivary gland, Spleen.
Medium only: carcinoid.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"B4GALT1" OR ABSTRACT:"B4GALT1" OR TITLE:"beta-1,4-galactosyltransferase 1" OR ABSTRACT:"beta-1,4-galactosyltransferase 1" OR TITLE:"Beta-1,4-galactosyltransferase 1" OR ABSTRACT:"Beta-1,4-galactosyltransferase 1" OR TITLE:"beta4Gal-T1" OR ABSTRACT:"beta4Gal-T1" OR TITLE:"GGTB2" OR ABSTRACT:"GGTB2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about B4GALT1, not a curated reading list.