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ATP7B (Copper-transporting ATPase 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.
CIViC holds 4 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin, Tranilast, Telmisartan and Amphotericin B.
In plain words · ATP7B (Copper-transporting ATPase 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
ATP7B (Copper-transporting ATPase 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.
No product in this corpus aims at ATP7B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ATP7B: RNA tissue enhanced (intestine 10 nTPM); high antibody staining in 12 normal tissues; highest cancer staining ovarian cancer (5 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ATP7B tissue; Open Targets ENSG00000123191 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Bull P.C. et al, Nat. Genet, 1993, "The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene". Source.
Sources: HGNC HGNC:870 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35670 (protein name, function text, keywords and locations (REST API)); CIViC gene ATP7B (4 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0))
Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. Location: Golgi apparatus, trans-Golgi network membrane; Late endosome; Golgi apparatus membrane; Cytoplasm (UniProt). Locus 13q14.3 (HGNC).
RNA: tissue enhanced (intestine 10 nTPM), detected in many normal tissues.
Medium: Appendix, Bone marrow, Breast, Bronchus, Cervix, Endometrium, Epididymis, Esophagus.
Medium only: endometrial cancer, glioma, head and neck cancer, renal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ATP7B" OR ABSTRACT:"ATP7B" OR TITLE:"ATPase copper transporting beta" OR ABSTRACT:"ATPase copper transporting beta" OR TITLE:"Copper-transporting ATPase 2" OR ABSTRACT:"Copper-transporting ATPase 2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATP7B, not a curated reading list.