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ATP2B3 (Plasma membrane calcium-transporting ATPase 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Lung cancer and 2 more.
ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.51, genetic association 0.00, somatic mutation 0.85). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.
In plain words · ATP2B3 (Plasma membrane calcium-transporting ATPase 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Lung cancer and 2 more.
ATP2B3 (Plasma membrane calcium-transporting ATPase 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Lung cancer and 2 more.
ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals.
No product in this corpus aims at ATP2B3 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1993. Earliest sequence paper UniProt cites for the protein: Stauffer T.P. et al, J. Biol. Chem, 1993, "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes". Source.
Sources: HGNC HGNC:816 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16720 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000067842 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: colorectal cancer 0.51, melanoma 0.50, skin cancer 0.55, breast cancer 0.58, lung cancer 0.51 (GraphQL API, CC0)); IntOGen ATP2B3 (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established. Location: Cell membrane; Presynaptic cell membrane (UniProt). Locus Xq28 (HGNC).
Query for this target: (TITLE:"ATP2B3" OR ABSTRACT:"ATP2B3" OR TITLE:"ATPase plasma membrane Ca2+ transporting 3" OR ABSTRACT:"ATPase plasma membrane Ca2+ transporting 3" OR TITLE:"Plasma membrane calcium-transporting ATPase 3" OR ABSTRACT:"Plasma membrane calcium-transporting ATPase 3" OR TITLE:"PMCA3" OR ABSTRACT:"PMCA3" OR TITLE:"CFAP39" OR ABSTRACT:"CFAP39" OR TITLE:"SCAX1" OR ABSTRACT:"SCAX1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATP2B3, not a curated reading list.