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ATF1 (Cyclic AMP-dependent transcription factor ATF-1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas, Colorectal cancer and Melanoma.
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.52, somatic mutation 0.98).
In plain words · ATF1 (Cyclic AMP-dependent transcription factor ATF-1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas, Colorectal cancer and Melanoma.
ATF1 (Cyclic AMP-dependent transcription factor ATF-1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas, Colorectal cancer and Melanoma.
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I.
No product in this corpus aims at ATF1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1989. Earliest sequence paper UniProt cites for the protein: Hai et al, Genes Dev, 1989, "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Source.
Sources: HGNC HGNC:783 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P18846 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000123268 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: colorectal cancer 0.51, melanoma 0.54, sarcoma 0.59 (GraphQL API, CC0))
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. Location: Nucleus (UniProt). Locus 12q13.12 (HGNC).
Query for this target: (TITLE:"ATF1" OR ABSTRACT:"ATF1" OR TITLE:"activating transcription factor 1" OR ABSTRACT:"activating transcription factor 1" OR TITLE:"Cyclic AMP-dependent transcription factor ATF-1" OR ABSTRACT:"Cyclic AMP-dependent transcription factor ATF-1" OR TITLE:"TREB36" OR ABSTRACT:"TREB36") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATF1, not a curated reading list.