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ASS1 (Argininosuccinate synthase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer and Sarcomas.
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyses the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Carboplatin, Cisplatin, Pegargiminase and Chloroquine and others.
In plain words · ASS1 (Argininosuccinate synthase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer and Sarcomas.
ASS1 (Argininosuccinate synthase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer and Sarcomas.
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals.
No product in this corpus aims at ASS1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ASS1: RNA group enriched (kidney 1,201 nTPM, liver 1,907 nTPM); blood lineage lineage enriched (dendritic cells 2 nTPM); high antibody staining in 5 normal tissues; highest cancer staining ovarian cancer (9 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Ovarian cancer, Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ASS1 tissue; Open Targets ENSG00000130707 associations
First described 1983. Earliest sequence paper UniProt cites for the protein: Bock H.-G.O. et al, Nucleic Acids Res, 1983, "Sequence for human argininosuccinate synthetase cDNA". Source.
Sources: HGNC HGNC:758 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P00966 (protein name, function text, keywords and locations (REST API)); CIViC gene ASS1 (2 evidence items, 0 assertions, 2 variants; diseases: Ovarian Cancer, Sarcoma (GraphQL API, CC0))
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyses the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. Location: Cytoplasm, cytosol (UniProt). Locus 9q34.11 (HGNC).
RNA: group enriched (kidney 1,201 nTPM, liver 1,907 nTPM), detected in many normal tissues. Blood: lineage enriched (dendritic cells 2 nTPM).
Medium: Adrenal gland, Bronchus, Colon, Fallopian tube, Gallbladder, Nasopharynx, Placenta, Rectum.
Medium only: melanoma, prostate cancer, renal cancer, testis cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ASS1" OR ABSTRACT:"ASS1" OR TITLE:"argininosuccinate synthase 1" OR ABSTRACT:"argininosuccinate synthase 1" OR TITLE:"Argininosuccinate synthase" OR ABSTRACT:"Argininosuccinate synthase" OR TITLE:"CTLN1" OR ABSTRACT:"CTLN1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ASS1, not a curated reading list.