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ASPSCR1 (Tether containing UBX domain for GLUT4) is a gene. The public catalogues list it as a drug target and a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas.
Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Enhances VCP methylation catalysed by VCPKMT.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.79, genetic association 0.09, somatic mutation 0.96). In OnCo, 1 product record names it (Cediranib).
In plain words · ASPSCR1 (Tether containing UBX domain for GLUT4) is a gene. The public catalogues list it as a drug target and a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas.
ASPSCR1 (Tether containing UBX domain for GLUT4) is a gene. The public catalogues list it as a drug target and a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas.
Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface.
No product in this corpus aims at ASPSCR1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Tumour-specific alteration: 1 of 1 medicines aimed at it name a mutant, fusion, exon or hotspot in their mechanism (Cediranib), an alteration absent from normal cells. HPA ASPSCR1: RNA low tissue specificity; no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 4 of scripts/fetch-target-specificity.ts.)
Sources: Wikipedia; Human Protein Atlas ASPSCR1 tissue; Open Targets ENSG00000169696 associations
First described 2001. Earliest sequence paper UniProt cites for the protein: Ladanyi et al, Oncogene, 2001, "The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25". Source.
Sources: HGNC HGNC:13825 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BZE9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000169696 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: sarcoma 0.56 (GraphQL API, CC0))
Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Enhances VCP methylation catalysed by VCPKMT. Location: Endomembrane system; Endoplasmic reticulum-Golgi intermediate compartment membrane; Cytoplasm; Nucleus (UniProt). Locus 17q25.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high; medium in Adipose tissue, Bone marrow, Breast, Bronchus, Caudate, Cerebral cortex and more.
No cancer stained high; medium in breast cancer, carcinoid, cervical cancer, colorectal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ASPSCR1" OR ABSTRACT:"ASPSCR1" OR TITLE:"ASPSCR1 tether for SLC2A4, UBX domain containing" OR ABSTRACT:"ASPSCR1 tether for SLC2A4, UBX domain containing" OR TITLE:"Tether containing UBX domain for GLUT4" OR ABSTRACT:"Tether containing UBX domain for GLUT4" OR TITLE:"UBXD9" OR ABSTRACT:"UBXD9" OR TITLE:"UBXN9" OR ABSTRACT:"UBXN9") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ASPSCR1, not a curated reading list.
Shares Cediranib, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.