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ALCAM (CD166 antigen) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Fluorouracil.
In plain words · ALCAM (CD166 antigen) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
ALCAM (CD166 antigen) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6.
No product in this corpus aims at ALCAM yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ALCAM: RNA tissue enriched (parathyroid gland 413 nTPM); blood lineage lineage enriched (dendritic cells 30 nTPM); high antibody staining in 18 normal tissues; highest cancer staining prostate cancer (12 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ALCAM tissue; Open Targets ENSG00000170017 associations
First described 1995. Earliest sequence paper UniProt cites for the protein: Bowen M.A. et al, J. Exp. Med, 1995, "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". Source.
Sources: HGNC HGNC:400 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13740 (protein name, function text, keywords and locations (REST API)); CIViC gene ALCAM (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation. Required for normal haematopoietic stem cell engraftment in the bone marrow. Location: Cell membrane; Cell projection, axon; Cell projection, dendrite; Secreted (UniProt). Locus 3q13.11 (HGNC).
RNA: tissue enriched (parathyroid gland 413 nTPM), detected in many normal tissues. Blood: lineage enriched (dendritic cells 30 nTPM).
Medium: Breast, Caudate, Cerebral cortex, Gallbladder, Salivary gland, Thyroid gland, Tonsil, Urinary bladder.
Medium only: carcinoid, melanoma, renal cancer.
HPA ALCAM tissue · HPA ALCAM pathology · HPA protein class: CD markers
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ALCAM" OR ABSTRACT:"ALCAM" OR TITLE:"activated leukocyte cell adhesion molecule" OR ABSTRACT:"activated leukocyte cell adhesion molecule" OR TITLE:"CD166 antigen" OR ABSTRACT:"CD166 antigen" OR TITLE:"CD166" OR ABSTRACT:"CD166") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ALCAM, not a curated reading list.