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AIMP2 (Aminoacyl tRNA synthase complex-interacting multifunctional protein 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer.
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · AIMP2 (Aminoacyl tRNA synthase complex-interacting multifunctional protein 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer.
AIMP2 (Aminoacyl tRNA synthase complex-interacting multifunctional protein 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer.
Required for assembly and stability of the aminoacyl-tRNA synthase complex.
No product in this corpus aims at AIMP2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA AIMP2: RNA tissue enhanced (skeletal muscle 151 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas AIMP2 tissue; Open Targets ENSG00000106305 associations
First described 1995. Earliest sequence paper UniProt cites for the protein: Nicolaides N.C. et al, Genomics, 1995, "Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene". Source.
Sources: HGNC HGNC:20609 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13155 (protein name, function text, keywords and locations (REST API)); CIViC gene AIMP2 (1 evidence items, 0 assertions, 1 variants; diseases: Lung Cancer (GraphQL API, CC0))
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. Location: Cytoplasm, cytosol; Nucleus (UniProt). Locus 7p22.1 (HGNC).
RNA: tissue enhanced (skeletal muscle 151 nTPM), detected in all normal tissues.
No normal tissue stained high; medium in Adipose tissue, Appendix, Bone marrow, Bronchus, Caudate, Cerebellum and more.
No cancer stained high; medium in carcinoid, colorectal cancer, endometrial cancer, glioma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"AIMP2" OR ABSTRACT:"AIMP2" OR TITLE:"aminoacyl tRNA synthetase complex interacting multifunctional protein 2" OR ABSTRACT:"aminoacyl tRNA synthetase complex interacting multifunctional protein 2" OR TITLE:"Aminoacyl tRNA synthase complex-interacting multifunctional protein 2" OR ABSTRACT:"Aminoacyl tRNA synthase complex-interacting multifunctional protein 2" OR TITLE:"p38" OR ABSTRACT:"p38" OR TITLE:"PRO0992" OR ABSTRACT:"PRO0992" OR TITLE:"JTV-1" OR ABSTRACT:"JTV-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AIMP2, not a curated reading list.