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ACTA1 (Actin, alpha skeletal muscle) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · ACTA1 (Actin, alpha skeletal muscle) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
ACTA1 (Actin, alpha skeletal muscle) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Location: Cytoplasm, cytoskeleton (UniProt).
No product in this corpus aims at ACTA1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ACTA1: RNA tissue enriched (skeletal muscle 123,974 nTPM); high antibody staining in 9 normal tissues. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ACTA1 tissue; Open Targets ENSG00000143632 associations
First described 1983. Earliest sequence paper UniProt cites for the protein: Hanauer et al, Nucleic Acids Res, 1983, "Isolation and characterization of cDNA clones for human skeletal muscle alpha actin". Source.
Sources: HGNC HGNC:129 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P68133 (protein name, function text, keywords and locations (REST API)); CIViC gene ACTA1 (1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0))
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1q42.13 (HGNC).
RNA: tissue enriched (skeletal muscle 123,974 nTPM), detected in many normal tissues.
Medium: Breast.
RNA cancer enriched: Head and Neck Squamous Cell Carcinoma 203 pTPM.
No cancer stained high; medium in breast cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ACTA1" OR ABSTRACT:"ACTA1" OR TITLE:"actin alpha 1, skeletal muscle" OR ABSTRACT:"actin alpha 1, skeletal muscle" OR TITLE:"Actin, alpha skeletal muscle" OR ABSTRACT:"Actin, alpha skeletal muscle" OR TITLE:"NEM3" OR ABSTRACT:"NEM3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACTA1, not a curated reading list.