Loading
ABCC10 (ATP-binding cassette sub-family C member 10) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May regulate the transport of organic compounds in testes across the blood-testis-barrier.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel.
In plain words · ABCC10 (ATP-binding cassette sub-family C member 10) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
ABCC10 (ATP-binding cassette sub-family C member 10) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells.
No product in this corpus aims at ABCC10 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ABCC10: RNA low tissue specificity; no normal tissue stained high; highest cancer staining ovarian cancer (2 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas ABCC10 tissue; Open Targets ENSG00000124574 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Hattori et al, DNA Res, 2000, "Characterization of long cDNA clones from human adult spleen". Source.
Sources: HGNC HGNC:52 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5T3U5 (protein name, function text, keywords and locations (REST API)); CIViC gene ABCC10 (1 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma (GraphQL API, CC0))
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May regulate the transport of organic compounds in testes across the blood-testis-barrier. Mediates intercellular propagation of antiviral immune signalling in early stages of infection. In RNA virus-infected cells, oligoadenylate synthase senses viral dsRNA and generates 2',5'-oligoadenylates (2-5A) which act as second messengers to activate RNASEL and type I interferon signalling to inhibit viral replication. This innate signalling pathway is locally extended and amplified by ABCC10, which exports 2-5A from virus-infected cells to cross-activates RNASEL in uninfected neighboring cells and confers protection against viral infection. Location: Cell membrane; Basolateral cell membrane; Basal cell membrane (UniProt). Locus 6p21.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high; medium in Appendix, Bone marrow, Breast, Bronchus, Cervix, Colon and more.
Medium only: carcinoid, cervical cancer, colorectal cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ABCC10" OR ABSTRACT:"ABCC10" OR TITLE:"ATP binding cassette subfamily C member 10" OR ABSTRACT:"ATP binding cassette subfamily C member 10" OR TITLE:"ATP-binding cassette sub-family C member 10" OR ABSTRACT:"ATP-binding cassette sub-family C member 10" OR TITLE:"EST182763" OR ABSTRACT:"EST182763" OR TITLE:"MRP7" OR ABSTRACT:"MRP7" OR TITLE:"SIMRP7" OR ABSTRACT:"SIMRP7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABCC10, not a curated reading list.