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In 1947-48 he showed that the folate antagonist aminopterin could send childhood leukaemia into remission, the first drug ever to do so. He then built Dana-Farber and, with Mary Lasker, won the 1971 National Cancer Act.
Sidney Farber (1903-1973) was a paediatric pathologist at Children's Hospital Boston who, in 1947, tested Yellapragada Subbarow's folic acid antagonists in children with acute leukaemia, a disease then universally and quickly fatal. His June 1948 New England Journal of Medicine paper reported temporary remissions in ten of sixteen children given aminopterin, the first demonstration that a drug could reverse a cancer, and the origin of methotrexate and of chemotherapy as a discipline. He founded the Children's Cancer Research Foundation in 1947, which became the Dana-Farber Cancer Institute, and the 1948 Jimmy Fund broadcast gave it a public base. In the 1950s he showed actinomycin D was active in Wilms tumour. With Mary Lasker he was the most effective scientific witness in the campaign for federal cancer funding that produced the National Cancer Act of 1971.
| Title | Journal | Year |
|---|---|---|
| Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin) | New England Journal of Medicine | 1948 |
| Chemotherapy in the Treatment of Leukemia and Wilms' Tumor | JAMA: The Journal of the American Medical Association | 1966 |
| SOME OBSERVATIONS ON THE EFFECT OF FOLIC ACID ANTAGONISTS ON ACUTE LEUKEMIA AND OTHER FORMS OF INCURABLE CANCER | Blood | 1949 |
Shares Emil "Tom" Frei III, Methotrexate, Rare and paediatric cancers without markets, Acute lymphoblastic leukaemia and the tags hero, pioneer.
Shares Emil "Tom" Frei III, Methotrexate, Acute lymphoblastic leukaemia, Cytotoxic chemotherapy and the tags hero, pioneer.
Shares Rare and paediatric cancers without markets, Acute lymphoblastic leukaemia, Cytotoxic chemotherapy and the tags hero, pioneer.
Shares Methotrexate, Cytotoxic chemotherapy and the tags hero, pioneer.
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