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Hans-Gustaf Ljunggren proposed the missing-self hypothesis of NK cell recognition.
Hans-Gustaf Ljunggren is Professor of Infectious Medicine at Karolinska Institutet and works at the Center for Infectious Medicine at Karolinska University Hospital. His specialisms are NK cell biology, missing-self recognition and cell therapy. With Klas Kärre he formulated the missing-self hypothesis, which explains how natural killer cells attack cells that lack MHC class I molecules. His Immunology Today paper set out this search for the missing self in NK cell recognition. The hypothesis is a foundation for NK-based cancer immunotherapy, including CAR-NK approaches. His publications are listed on PubMed.
| Title | Journal | Year |
|---|---|---|
| In search of the 'missing self': MHC molecules and NK cell recognition | Immunology Today | 1990 |