{"entity":{"id":"hans-gustaf-ljunggren","kind":"person","name":"Hans-Gustaf Ljunggren","aka":[],"tldr":"Hans-Gustaf Ljunggren proposed the missing-self hypothesis of NK cell recognition.","summary":"Hans-Gustaf Ljunggren is Professor of Infectious Medicine at Karolinska Institutet and works at the Center for Infectious Medicine at Karolinska University Hospital. His specialisms are NK cell biology, missing-self recognition and cell therapy. With Klas Kärre he formulated the missing-self hypothesis, which explains how natural killer cells attack cells that lack MHC class I molecules. His Immunology Today paper set out this search for the missing self in NK cell recognition. The hypothesis is a foundation for NK-based cancer immunotherapy, including CAR-NK approaches. His publications are listed on PubMed.","asOf":"2026-09-08","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Ljunggren%20HG%5BAuthor%5D%20missing%20self"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["car-nk-macrophage"],"targets":[],"drugs":[],"companies":[],"institutions":["karolinska"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Infectious Medicine, Karolinska Institutet; Center for Infectious Medicine","institutionId":"karolinska","specialisms":["NK cell biology","Missing-self recognition","Cell therapy"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Ljunggren%20HG%5BAuthor%5D%20missing%20self"}],"papers":[{"title":"In search of the 'missing self': MHC molecules and NK cell recognition","journal":"Immunology Today","year":1990,"doi":"10.1016/0167-5699(90)90097-S"}],"orcid":"0000-0003-0908-7387"},"route":"/people/hans-gustaf-ljunggren/","neighbours":{"technology":[{"id":"car-nk-macrophage","kind":"technology","name":"CAR-NK & CAR-macrophage","route":"/technologies/car-nk-macrophage/"}],"institution":[{"id":"karolinska","kind":"institution","name":"Karolinska University Hospital","route":"/institutions/karolinska/"}]}}