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Italian haematologist who led APL0406, the trial that showed acute promyelocytic leukaemia can be cured with all-trans retinoic acid and arsenic trioxide alone, without chemotherapy.
Francesco Lo-Coco was professor of haematology at the University of Rome Tor Vergata and a leading investigator of the Italian GIMEMA group. He was first author of the 2013 New England Journal of Medicine report of APL0406, the Italian-German trial that showed all-trans retinoic acid plus arsenic trioxide was at least as effective as ATRA plus chemotherapy in low- and intermediate-risk acute promyelocytic leukaemia, with far fewer haematological complications. The chemotherapy-free regimen became the standard of care. He died in 2019.
| Title | Journal | Year |
|---|---|---|
| APL0406: retinoic acid plus arsenic trioxide without chemotherapy for low- and intermediate-risk acute promyelocytic leukaemia | New England Journal of Medicine | 2013 |
Shares Acute myeloid leukaemia and the tags leukaemia, trialist.
Shares Acute myeloid leukaemia and the tags leukaemia, trialist.
Shares Acute promyelocytic leukaemia, Acute myeloid leukaemia and the tag leukaemia.
Shares the tags leukaemia, trialist.
Shares the tags leukaemia, trialist.
Shares the tags leukaemia, trialist.
Shares the tags leukaemia, trialist.
Shares Acute promyelocytic leukaemia, Acute myeloid leukaemia.