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Gustave Roussy thoracic oncologist on the IFCT board, widely published on BRAF- and EGFR-targeted therapy in lung cancer.
David Planchard is a medical oncologist at Gustave Roussy (Villejuif) and a member of the IFCT board. He has led or co-led pivotal trials of targeted agents in oncogene-driven non-small cell lung cancer, including BRAF V600E-mutant disease, and contributes to ESMO clinical practice guidelines for metastatic NSCLC.
| Title | Journal | Year |
|---|---|---|
| Dabrafenib plus trametinib in patients with previously treated BRAFV600E-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial | The Lancet Oncology | 2016 |
| Osimertinib with or without Chemotherapy in EGFR -Mutated Advanced NSCLC | New England Journal of Medicine | 2023 |
| Dabrafenib in patients with BRAFV600E-positive advanced non-small-cell lung cancer: a single-arm, multicentre, open-label, phase 2 trial | The Lancet Oncology | 2016 |
For a patient weighing the FLAURA2 regimen against osimertinib alone, the extra toxicity is front-loaded: the hardest months are the four induction cycles, and once pemetrexed stops the profile returns to that of osimertinib by itself. Kidney function deserves watching during pemetrexed maintenance.
Adding chemotherapy to osimertinib delays progression. Whether it extends life, and whether the same benefit could be had by giving the chemotherapy later to the patients who need it, is what the overall survival analysis and the registry watch on this roadmap are for.
Shares Unresectable stage III non-small-cell lung cancer, EGFR-mutated non-small-cell lung cancer, Non-small-cell lung cancer and the tags clinician-scientist, lung cancer, targeted therapy.
Shares Non-small-cell lung cancer and the tags clinician-scientist, lung cancer, targeted therapy.
Shares Intergroupe Francophone de Cancérologie Thoracique, Non-small-cell lung cancer and the tags clinician-scientist, lung cancer.
Shares Non-small-cell lung cancer and the tags clinician-scientist, lung cancer.
Shares Non-small-cell lung cancer and the tags clinician-scientist, lung cancer.
Shares Non-small-cell lung cancer and the tags clinician-scientist, lung cancer.
Shares Non-small-cell lung cancer and the tags clinician-scientist, lung cancer.
Shares Non-small-cell lung cancer and the tags clinician-scientist, lung cancer.