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Showed that colorectal cancers grow as a 'Big Bang' and that metastasis can be seeded years before diagnosis.
Christina Curtis developed the Big Bang model showing that colorectal tumours acquire their intratumour heterogeneity early and grow without stringent selection, and used computational modelling of paired primary-metastasis genomes to show that metastatic seeding often occurs years before the primary tumour is detected. She co-led METABRIC and her laboratory now studies how germline immunogenetics shapes somatic tumour evolution.
| Title | Journal | Year |
|---|---|---|
| A Big Bang model of human colorectal tumor growth | Nature Genetics | 2015 |
| Quantitative evidence for early metastatic seeding in colorectal cancer | Nature Genetics | 2019 |
| Gerlinger: a single biopsy misses most of the mutations in a kidney tumour | New England Journal of Medicine | 2012 |
Shares Whole-exome & whole-genome sequencing and the tags computational, genomics.
Shares Nature Genetics and the tag genomics.
Shares Whole-exome & whole-genome sequencing, HR-positive / HER2-negative breast cancer and the tag genomics.
Shares Whole-exome & whole-genome sequencing, HR-positive / HER2-negative breast cancer and the tag genomics.
Shares Whole-exome & whole-genome sequencing and the tag genomics.
Shares Whole-exome & whole-genome sequencing and the tag genomics.
Shares Whole-exome & whole-genome sequencing and the tag genomics.
Shares Nature Genetics, Whole-exome & whole-genome sequencing.