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Saijuan Chen helped turn acute promyelocytic leukaemia from a leukaemia that often killed within weeks into one of the most curable, by showing how retinoic acid and arsenic act and combining them.
With Zhu Chen and Zhen-Yi Wang at the Shanghai Institute of Hematology, Chen dissected the PML-RARA fusion and the mechanisms of all-trans retinoic acid and arsenic trioxide, and led the trials showing that the two drugs together produce high-quality, durable remissions in newly diagnosed APL (PNAS 2004), the basis of chemotherapy-free APL treatment now standard worldwide. Academician of the Chinese Academy of Engineering; her genomics work spans AML, T-ALL and lymphoma.
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Shares Tretinoin (all-trans retinoic acid, ATRA), Arsenic trioxide, Acute myeloid leukaemia.
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