{"entity":{"id":"chen-saijuan","kind":"person","name":"Saijuan Chen","aka":["Chen Sai-Juan","陈赛娟"],"tldr":"Saijuan Chen helped turn acute promyelocytic leukaemia from a leukaemia that often killed within weeks into one of the most curable, by showing how retinoic acid and arsenic act and combining them.","summary":"With Zhu Chen and Zhen-Yi Wang at the Shanghai Institute of Hematology, Chen dissected the PML-RARA fusion and the mechanisms of all-trans retinoic acid and arsenic trioxide, and led the trials showing that the two drugs together produce high-quality, durable remissions in newly diagnosed APL (PNAS 2004), the basis of chemotherapy-free APL treatment now standard worldwide. Academician of the Chinese Academy of Engineering; her genomics work spans AML, T-ALL and lymphoma.","asOf":"2026-09-10","links":[{"label":"Ruijin Hospital","url":"https://www.rjh.com.cn/"},{"label":"PubMed author search","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Chen%20SJ%5BAuthor%5D%20acute%20promyelocytic%20leukemia%20Shanghai%20Institute%20of%20Hematology"}],"tags":["china"],"related":[],"cancers":["aml"],"sections":[],"technologies":[],"targets":[],"drugs":["tretinoin-atra","arsenic-trioxide"],"companies":[],"institutions":["ruijin-hospital"],"pathways":[],"terms":[],"trials":[],"people":["chen-zhu"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor; Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine","institutionId":"ruijin-hospital","specialisms":["Acute promyelocytic leukaemia","Leukaemia genomics","Differentiation therapy"],"profiles":[{"label":"Ruijin Hospital","url":"https://www.rjh.com.cn/"},{"label":"PubMed author search","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Chen%20SJ%5BAuthor%5D%20acute%20promyelocytic%20leukemia%20Shanghai%20Institute%20of%20Hematology"}],"papers":[{"title":"All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia","journal":"PNAS","year":2004,"doi":"10.1073/pnas.0400053101"}]},"route":"/people/chen-saijuan/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"}],"drug":[{"id":"arsenic-trioxide","kind":"drug","name":"Arsenic trioxide","route":"/drugs/arsenic-trioxide/"},{"id":"tretinoin-atra","kind":"drug","name":"Tretinoin (all-trans retinoic acid, ATRA)","route":"/drugs/tretinoin-atra/"}],"institution":[{"id":"ruijin-hospital","kind":"institution","name":"Ruijin Hospital, Shanghai Jiao Tong University","route":"/institutions/ruijin-hospital/"}],"person":[{"id":"chen-zhu","kind":"person","name":"Zhu Chen","route":"/people/chen-zhu/"}]}}