Bradley E. Bernstein

Bradley E. Bernstein is an Institute Member at the Broad Institute of MIT and Harvard and Chair of Cancer Biology at Dana-Farber. He is an epigenomicist known for defining bivalent chromatin domains and for using single-cell approaches to show how glioma and other tumours exploit epigenetic plasticity to switch identities and resist drugs. His selected paper uses single-cell RNA sequencing to reveal intratumoural heterogeneity in primary glioblastoma. His laboratory continues to map chromatin landscapes in cancer, with relevance to epigenetic drugs and single-cell and spatial profiling.