{"entity":{"id":"bradley-bernstein","kind":"person","name":"Bradley E. Bernstein","aka":[],"tldr":"Bradley Bernstein mapped the chromatin landscapes that let cancer cells switch identities and resist drugs.","summary":"Bradley E. Bernstein is an Institute Member at the Broad Institute of MIT and Harvard and Chair of Cancer Biology at Dana-Farber. He is an epigenomicist known for defining bivalent chromatin domains and for using single-cell approaches to show how glioma and other tumours exploit epigenetic plasticity to switch identities and resist drugs. His selected paper uses single-cell RNA sequencing to reveal intratumoural heterogeneity in primary glioblastoma. His laboratory continues to map chromatin landscapes in cancer, with relevance to epigenetic drugs and single-cell and spatial profiling.","asOf":"2026-09-08","links":[{"label":"Broad bio","url":"https://www.broadinstitute.org/bios/bradley-e-bernstein"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Bernstein%20BE%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["glioblastoma"],"sections":[],"technologies":["single-cell-spatial","epigenetic-drugs"],"targets":[],"drugs":[],"companies":[],"institutions":["broad-institute"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Institute Member, Broad; Chair, Cancer Biology, Dana-Farber","institutionId":"broad-institute","specialisms":["Epigenomics","Chromatin","Glioma"],"profiles":[{"label":"Broad bio","url":"https://www.broadinstitute.org/bios/bradley-e-bernstein"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Bernstein%20BE%5BAuthor%5D"}],"papers":[{"title":"Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma","journal":"Science","year":2014,"url":"https://doi.org/10.1126/science.1254257","doi":"10.1126/science.1254257"}]},"route":"/people/bradley-bernstein/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"technology":[{"id":"epigenetic-drugs","kind":"technology","name":"Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET)","route":"/technologies/epigenetic-drugs/"},{"id":"single-cell-spatial","kind":"technology","name":"Single-cell & spatial profiling","route":"/technologies/single-cell-spatial/"}],"institution":[{"id":"broad-institute","kind":"institution","name":"Broad Institute of MIT and Harvard","route":"/institutions/broad-institute/"}]}}