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This study discovered that adenoid cystic carcinomas of the salivary gland and breast are driven by a fusion of the MYB and NFIB genes, providing the defining molecular feature of the tumour and a diagnostic marker.
Molecular study identifying a recurrent t(6;9) translocation in adenoid cystic carcinoma that fuses the MYB oncogene to NFIB, leading to MYB overexpression by loss of microRNA-mediated repression, present in the majority of tumours of both head and neck and breast origin.
MYB immunostaining and MYB-NFIB fusion testing are now diagnostic tools for adenoid cystic carcinoma, and MYB is the principal target of therapeutic research in the disease.