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This review summarises how childhood acute lymphoblastic leukaemia became curable in nine of ten children through risk-adapted chemotherapy, and how genomic subtypes such as Ph-like and infant leukaemia are shaping the next generation of targeted treatment.
Review of the epidemiology, genomic classification (including Ph-like ALL, IKZF1 alterations, KMT2A rearrangements, hypodiploidy), risk stratification by measurable residual disease, treatment phases, outcomes approaching 90 percent survival, late effects, relapse and emerging immunotherapies for childhood ALL.
The structure of the paediatric ALL subtype pages, from risk groups to new targeted and immune therapies, follows the framework in this review.
Shares Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like or BCR::ABL1-like ALL), New England Journal of Medicine.
Shares Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like or BCR::ABL1-like ALL), New England Journal of Medicine.
Shares Infant acute lymphoblastic leukaemia (KMT2A-rearranged, under one year), New England Journal of Medicine.
Shares Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like or BCR::ABL1-like ALL), Infant acute lymphoblastic leukaemia (KMT2A-rearranged, under one year), High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL).
Shares Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like or BCR::ABL1-like ALL), High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL).
Shares Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like or BCR::ABL1-like ALL), High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL).
Shares Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like or BCR::ABL1-like ALL), Infant acute lymphoblastic leukaemia (KMT2A-rearranged, under one year), High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL).
Shares Infant acute lymphoblastic leukaemia (KMT2A-rearranged, under one year), High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL).