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Sequencing 262 gallbladder tumours from Chile, China, India, Japan and South Korea showed that the mutations differ by country and ancestry, with Chinese tumours carrying the most mutations and Chilean the fewest.
Whole-exome sequencing of 262 gallbladder cancer tumour-normal pairs from Chilean, Chinese, Indian, Japanese and South Korean patients, analysed with a unified pipeline for gene mutations and mutational signatures, with individual ancestry proportions estimated and related to genomic profiles. Tumour mutation burden was highest in China and lowest in Chile. The authors conclude that gallbladder cancer shows marked geographic and genetic heterogeneity in mutation profiles with implications for prevention and targeted therapy in high-incidence regions. Funded by the EU Horizon 2020 programme (grant 825741).
Targeted therapy prevalence estimates from one country may not hold in another, so a UK cohort, with its own ancestry mix, would need its own molecular survey before assuming HER2 or other rates from Asian or Latin American series.
Shares Redesign Chile's prophylactic cholecystectomy programme around risk, and evaluate it properly, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Redesign Chile's prophylactic cholecystectomy programme around risk, and evaluate it properly, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Redesign Chile's prophylactic cholecystectomy programme around risk, and evaluate it properly, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, TP53, HER2, Comprehensive genomic profiling and the tag gallbladder-evidence.
Shares Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.