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The other widely used cancer quality of life questionnaire, developed in the United States alongside the EORTC QLQ-C30, covering physical, social and family, emotional and functional wellbeing and extended by cancer-specific modules.
Cella and colleagues developed and validated the Functional Assessment of Cancer Therapy general scale (FACT-G), a self-administered questionnaire for patients receiving cancer treatment, through item generation with patients and clinicians, item reduction and testing in patients with a range of cancers. The scale covers physical wellbeing, social and family wellbeing, emotional wellbeing and functional wellbeing, showed good reliability and validity, distinguished patients by performance status and stage, and was sensitive to change over time. Disease-, treatment- and symptom-specific subscales were built on top of the core.
FACT-G and the EORTC QLQ-C30 are the two instruments behind most patient-reported quality of life results in cancer trials and regulatory submissions. Knowing which was used matters when comparing quality of life claims between trials.