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Combining gene expression and methylation data from 763 medulloblastomas split the four subgroups into twelve subtypes with distinct genetics and survival, refining who is at high and low risk within each group.
Integrative clustering of 763 primary medulloblastomas using DNA methylation and gene expression identifying twelve subtypes: two WNT, four SHH, three group 3 and three group 4, each with distinct copy-number alterations, mutations, age distribution and survival.
Subtype-level classification, particularly separating infant and TP53-mutant SHH tumours and MYC-amplified group 3 tumours, guides current risk stratification and trial design.
Shares WNT-activated medulloblastoma, Group 3 and group 4 medulloblastoma (non-WNT/non-SHH), SHH-activated medulloblastoma.
Shares WNT-activated medulloblastoma, Group 3 and group 4 medulloblastoma (non-WNT/non-SHH).
Shares WNT-activated medulloblastoma, Group 3 and group 4 medulloblastoma (non-WNT/non-SHH), SHH-activated medulloblastoma.
Shares WNT-activated medulloblastoma, Group 3 and group 4 medulloblastoma (non-WNT/non-SHH), SHH-activated medulloblastoma.
Shares WNT-activated medulloblastoma, Group 3 and group 4 medulloblastoma (non-WNT/non-SHH), SHH-activated medulloblastoma.
Shares WNT-activated medulloblastoma, Group 3 and group 4 medulloblastoma (non-WNT/non-SHH).
Shares WNT-activated medulloblastoma, Group 3 and group 4 medulloblastoma (non-WNT/non-SHH), SHH-activated medulloblastoma.
Shares WNT-activated medulloblastoma, Group 3 and group 4 medulloblastoma (non-WNT/non-SHH), SHH-activated medulloblastoma.