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Trials sometimes quietly swap the outcome they promised to measure for one that looks better. Software can compare the registered plan with the published paper and flag the switch.
The COMPare project manually compared registered and published outcomes in five top journals and found widespread undisclosed switching. Registry entries and publications are now structured enough for automated comparison, and pre-specified statistical analysis plans are increasingly public. A continuously running monitor that flags outcome discrepancies in oncology trials, notifies journals and posts findings publicly would deter switching.
Shares ClinicalTrials.gov, Failures are hidden, Trial design, endpoints and cost.
Shares ClinicalTrials.gov, Failures are hidden, PubMed & Europe PMC.
Shares Run automated statistics and image checks on every cancer manuscript before review, Trial design, endpoints and cost.
Shares ClinicalTrials.gov, Trial design, endpoints and cost.
Shares ClinicalTrials.gov, Failures are hidden.
Shares ClinicalTrials.gov, Failures are hidden.
Shares Failures are hidden, Trial design, endpoints and cost.
Shares ClinicalTrials.gov, Trial design, endpoints and cost.