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About one in a hundred people who develop diabetes after 50, more if they are losing weight, have pancreatic cancer. A simple score could send them for a scan or blood test.
New diabetes after 50, especially with weight loss, can be an early sign of pancreatic cancer, so this idea builds an automated EHR alert around the Mayo Clinic ENDPAC score, which uses age, weight change and glucose trajectory, and sends high-scoring patients for CT or MRI or a CA19-9 or methylation blood test. New-onset diabetes is a paraneoplastic effect of early pancreatic cancer, the window is one to three years, and the population can be enumerated in primary care. The aim is to raise the share of pancreatic cancers among new diabetics diagnosed at a resectable stage. A cluster-randomised trial across primary care networks would measure stage at diagnosis, resection rate and scans per cancer. At early-clinical maturity, it addresses the bottleneck The hardest cancers are found late.
Shares Early detection of cancer, Mayo Clinic, Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, CT (computed tomography).
Shares Early detection of cancer, Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, The hardest cancers are found late, Pancreatic ductal adenocarcinoma.
Shares Early detection of cancer, MRI, The hardest cancers are found late, Liquid biopsy (ctDNA).
Shares Early detection of cancer, The hardest cancers are found late, Liquid biopsy (ctDNA).
Shares Early detection of cancer, The hardest cancers are found late.
Shares Early detection of cancer, CT (computed tomography), The hardest cancers are found late, Pancreatic ductal adenocarcinoma.
Shares Early detection of cancer, The hardest cancers are found late.
Shares Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, MRI, Pancreatic ductal adenocarcinoma.