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PSA screening finds harmless prostate cancers that would never cause trouble. Selecting men by PSA plus a polygenic risk score, then MRI before any biopsy and targeted biopsy only for PI-RADS 4 to 5 lesions, finds the dangerous cancers and skips the rest; GOTEBORG-2 showed MRI-targeted biopsy halves overdiagnosis.
GOTEBORG-2 showed MRI-targeted biopsy halves overdiagnosis; BARCODE1 showed polygenic-score-selected men have high rates of clinically significant cancer. The UK TRANSFORM trial will compare pathways. Propose a national screening design combining PRS/PSA pre-selection, MRI, and targeted biopsy only for PI-RADS 4-5 lesions.
Shares Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction, Polygenic risk score (PRS), Judge a prostate screening programme on metastatic presentation, not on incidence or mortality, The Institute of Cancer Research.
Shares PI-RADS (Prostate Imaging Reporting and Data System), Publish a per-lesion miss rate for every prostate MRI service before it is allowed to guide focal treatment, Overdiagnosis and false alarms, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch.
Shares Polygenic risk score (PRS), PI-RADS (Prostate Imaging Reporting and Data System), Judge a prostate screening programme on metastatic presentation, not on incidence or mortality, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch.
Shares Judge a prostate screening programme on metastatic presentation, not on incidence or mortality, Overdiagnosis and false alarms, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Prostate cancer.
Shares PI-RADS (Prostate Imaging Reporting and Data System), Publish a per-lesion miss rate for every prostate MRI service before it is allowed to guide focal treatment, Overdiagnosis and false alarms, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch.
Shares PI-RADS (Prostate Imaging Reporting and Data System), Publish a per-lesion miss rate for every prostate MRI service before it is allowed to guide focal treatment, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, MRI.
Shares PI-RADS (Prostate Imaging Reporting and Data System), Publish a per-lesion miss rate for every prostate MRI service before it is allowed to guide focal treatment, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Prostate cancer.
Shares PI-RADS (Prostate Imaging Reporting and Data System), Publish a per-lesion miss rate for every prostate MRI service before it is allowed to guide focal treatment, Overdiagnosis and false alarms, MRI.