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Air pollution causes lung cancer in people who never smoked. Clean air zones and coal phase-outs should be tracked against never-smoker lung cancer rates.
Fine particulate pollution promotes EGFR-mutant lung cancer in never-smokers (Francis Crick Institute work). Propose linked-data evaluation of air-quality interventions (London ULEZ, Chinese coal-to-gas conversion) with never-smoker, EGFR-mutant lung cancer incidence as endpoints, and pre-registered modelling.
It reframes air quality as cancer policy rather than respiratory policy, and it explains the shape of lung cancer in never-smokers: the mutations are common and mostly silent, and what differs is whether something inflames the tissue enough to let one of them grow.
Relapse after surgery is driven by particular subclones that can be identified in the primary tumour and tracked in blood, which argues for evolution-aware adjuvant strategies. The pollution finding reframes carcinogenesis: some agents promote already-mutant cells rather than causing mutations.
One bottleneck page and 27 idea pages on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
Doll and Hill's 1950 study is where the evidence that smoking causes cancer begins. Everything from cigarette warnings and tax to smoke-free laws and lung screening eligibility descends from this study and the cohort that followed it.
Shares Doll and Hill 1950: the case-control study that tied smoking to lung cancer, Lung cancer roadmap: from Doll and Hill and the naming of tobacco, through the cytotoxic plateau, computed tomography screening, EGFR and ALK, immunotherapy by PD-L1, the perioperative trials and PACIFIC, to DLL3 in small-cell disease and a 2032 registry watch, Prevention we already have is not deployed, Non-small-cell lung cancer.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed, Non-small-cell lung cancer.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed, Non-small-cell lung cancer.
Shares Doll and Hill 1950: the case-control study that tied smoking to lung cancer, Lung cancer roadmap: from Doll and Hill and the naming of tobacco, through the cytotoxic plateau, computed tomography screening, EGFR and ALK, immunotherapy by PD-L1, the perioperative trials and PACIFIC, to DLL3 in small-cell disease and a 2032 registry watch, Prevention we already have is not deployed, Non-small-cell lung cancer.
Shares Doll and Hill 1950: the case-control study that tied smoking to lung cancer, Prevention we already have is not deployed, Non-small-cell lung cancer.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed, Non-small-cell lung cancer.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed.