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Build a drug company that does not need profits, modelled on the ones that developed new tuberculosis and sleeping-sickness drugs, to take on rare, paediatric and undruggable cancers.
A product development partnership (PDP) for oncology, on the model of the Drugs for Neglected Diseases initiative, TB Alliance and Medicines for Malaria Venture: philanthropic and public core funding, in-licensing of shelved or academic assets, virtual development through contract organisations, trials run with academic networks, and pricing at cost plus a margin reinvested in the pipeline. Target areas are those where the commercial case is weak but the science is ready: paediatric solid tumours, rare fusion-driven cancers, repurposed generics, and de-escalation regimens. The PDP can also be the licensee of last resort for assets that companies abandon.
Shares Advance market commitments for paediatric and rare cancer drugs, Incentives reward me-too drugs and marginal gains, Neuroblastoma (paediatric), Rare and paediatric cancers without markets.
Shares Incentives reward me-too drugs and marginal gains, Neuroblastoma (paediatric), Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
Shares Milestone-based venture philanthropy with royalties recycled into the pipeline, The valley of death between lab and product, Incentives reward me-too drugs and marginal gains.
Shares Neuroblastoma (paediatric), Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST), Biliary tract cancer (cholangiocarcinoma).
Shares The valley of death between lab and product, Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST), Biliary tract cancer (cholangiocarcinoma).
Shares Neuroblastoma (paediatric), Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
Shares Neuroblastoma (paediatric), Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
Shares Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST), Biliary tract cancer (cholangiocarcinoma).